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Integrative Cancer Therapies, Vol. 7, No. 2, 90-95 (2008)
DOI: 10.1177/1534735408319060

Tumor Versus Tumor-Associated Macrophages: How Hot is the Link?

C. Guruvayoorappan, PhD

Department of Biotechnology, Karunya University, Tamil Nadu, India, gurukarunya{at}gmail.com

One of the functions of macrophages is to provide a defense mechanism against tumor cells. In contrast, tumor-associated macrophages (TAMs), which represent the major inflammatory component of the stroma of many tumors, are associated with tumor progression and metastasis. TAMs, in contrast with normal macrophages, exhibit the M2 phenotype, and thereby exhibit pro-tumoral functions, including angiogenesis and matrix remodeling. This review will discuss the role of TAMs in tumor progression and provide an overview of their significant part in tumor metastasis and angiogenesis.

Key Words: tumor-associated macrophages • angiogenesis • metastasis • natural products


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